Description
Zycortal Suspension for Dogs – Addison’s Disease Treatment (25mg/ml)
Zycortal Suspension is a long-acting injectable mineralocorticoid replacement therapy manufactured by Dechra for the treatment of canine Addison’s disease (hypoadrenocorticism). This FDA-approved veterinary medication helps dogs with primary adrenal insufficiency maintain proper electrolyte balance and live healthy, active lives.
The active ingredient, desoxycorticosterone pivalate (DOCP) at 25mg/ml concentration, is a synthetic analog of aldosterone the hormone that dogs with Addison’s disease cannot produce in sufficient quantities. Administered as a monthly subcutaneous injection by your veterinarian, Zycortal effectively controls sodium and potassium levels, addressing the life-threatening electrolyte imbalances caused by hypoadrenocorticism.
Since its FDA approval, Zycortal Suspension has become a trusted treatment option for veterinarians managing canine Addison’s disease. The convenient once-monthly dosing schedule and consistent therapeutic results make it easier for pet owners to maintain their dog’s treatment regimen compared to daily oral medications.
A valid veterinary prescription is required to purchase this medication. Your veterinarian must diagnose your dog with Addison’s disease and prescribe Zycortal before we can dispense it.
Understanding Canine Addison’s Disease
Addison’s disease, or hypoadrenocorticism, occurs when a dog’s adrenal glands fail to produce adequate amounts of essential hormones, particularly aldosterone and cortisol. This condition can be life-threatening if left untreated.
Common Symptoms Include:
- Lethargy and weakness
- Loss of appetite and weight loss
- Vomiting and diarrhea
- Increased thirst and urination
- Trembling or shaking
- Collapse during stress (Addisonian crisis)
Diagnosis: Your veterinarian will diagnose Addison’s disease through blood tests, including an ACTH stimulation test, along with evaluation of electrolyte levels (typically showing high potassium and low sodium).
Treatment Approach: Dogs with Addison’s require lifelong hormone replacement therapy. Zycortal addresses the mineralocorticoid deficiency, while glucocorticoid supplementation (prednisone or prednisolone) may also be prescribed to replace cortisol.
How Zycortal Suspension Works
Zycortal contains desoxycorticosterone pivalate (DOCP), a synthetic mineralocorticoid that mimics the action of aldosterone. When administered, DOCP acts on the kidneys to:
Restore Electrolyte Balance: Promotes sodium retention and potassium excretion, correcting the dangerous imbalances characteristic of Addison’s disease.
Maintain Blood Pressure: Helps regulate blood volume and pressure by controlling sodium and water retention.
Prevent Addisonian Crisis: Provides consistent hormone replacement that prevents life-threatening episodes triggered by stress or illness.
The long-acting formulation allows for once-monthly administration, releasing medication gradually over approximately 25-30 days. This sustained-release mechanism maintains stable hormone levels without the peaks and valleys associated with daily oral medications.
Product Specifications
| Specification | Details |
|---|---|
| Active Ingredient | Desoxycorticosterone pivalate (DOCP) |
| Concentration | 25 mg/ml |
| Dosage Form | Injectable suspension |
| Administration Route | Subcutaneous injection |
| Frequency | Every 25-30 days (typically monthly) |
| Packaging | Multi-dose vial, sterile suspension |
| Manufacturer | Dechra Veterinary Products |
| FDA Status | Approved for veterinary use |
| Storage | Refrigerate at 2-8°C (36-46°F) |
| Prescription Status | Yes – Valid veterinary prescription required |
Important: Shake vial well before each use to ensure proper suspension of medication.
Dosage & Administration
Standard Dosing: The initial dose is 2.2 mg per kg (1 mg per lb) of body weight, administered subcutaneously.
Administration Schedule: Injections are typically given every 25-30 days. Your veterinarian will determine the optimal dosing interval based on your dog’s response to treatment and electrolyte monitoring results.
Dosage Adjustments: Your veterinarian may adjust the dose or frequency based on:
- Periodic blood tests monitoring sodium and potassium levels
- Clinical response and symptom control
- Your dog’s individual metabolism and needs
Who Administers: Zycortal injections must be given by your veterinarian or trained veterinary staff. This is not a medication pet owners administer at home.
Monitoring Required: Regular veterinary checkups and blood work are essential to ensure proper electrolyte balance and adjust treatment as needed. Most dogs require blood tests 2-4 weeks after starting therapy and then every 3-6 months once stabilized.
Side Effects & Safety Information
Common Side Effects
Zycortal Suspension is generally well-tolerated when used at prescribed doses. Potential side effects may include:
- Injection site reactions (pain, swelling, or redness)
- Increased thirst and urination
- Increased appetite
- Panting
- Restlessness
Most side effects are mild and resolve on their own. Contact your veterinarian if symptoms persist or worsen.
Serious Side Effects (Rare)
Seek immediate veterinary care if your dog experiences:
- Severe lethargy or weakness
- Persistent vomiting or diarrhea
- Collapse or difficulty breathing
- Signs of allergic reaction (facial swelling, hives, difficulty breathing)
Contraindications & Precautions
Do Not Use In:
- Dogs with known hypersensitivity to DOCP
- Dogs with congestive heart failure or severe kidney disease
- Pregnant or nursing dogs (use only if benefits outweigh risks)
Use With Caution: Inform your veterinarian of all medications and supplements your dog is taking, particularly diuretics, ACE inhibitors, or NSAIDs, as interactions may occur.
Zycortal vs. Percorten-V: What’s the Difference?
Both Zycortal and Percorten-V contain the same active ingredient (DOCP) at the same concentration (25mg/ml) and are used to treat canine Addison’s disease. The primary differences are:
Manufacturer: Zycortal is manufactured by Dechra, while Percorten-V is made by Elanco.
Formulation: Minor differences in inactive ingredients may exist, but both products are therapeutically equivalent.
Availability & Cost: Pricing and availability may vary between products depending on supplier and market conditions. Your veterinarian can help determine which option is most appropriate and accessible for your dog.
Interchangeability: Dogs can typically be switched between products if needed, though your veterinarian should supervise any transition.
Treatment Costs & Considerations
Typical Costs: The cost of Zycortal treatment varies based on your dog’s size, as larger dogs require higher doses. Monthly treatment costs typically range from $50-$200+ per injection, plus veterinary examination and monitoring fees.
Long-Term Commitment: Dogs with Addison’s disease require lifelong treatment. Budget for monthly medication costs, periodic veterinary visits, and regular blood work monitoring.
Pet Insurance: Many pet insurance policies cover prescription medications for diagnosed conditions. Check with your insurance provider about coverage for Addison’s disease treatment.
Generic Alternatives: Currently, no generic version of DOCP is available. Percorten-V is the primary alternative product with the same active ingredient.
Frequently Asked Questions
How quickly does Zycortal start working?
Zycortal begins working within hours of administration. Most dogs show improvement in energy, appetite, and overall demeanor within 24-48 hours of their first injection. However, it may take 2-4 weeks to fully stabilize electrolyte levels and assess optimal dosing. Your veterinarian will monitor progress through blood tests and clinical evaluation.
What happens if my dog misses a dose of Zycortal?
If your dog misses their scheduled injection, contact your veterinarian immediately to reschedule. While Zycortal provides coverage for approximately 25-30 days, delaying treatment can lead to electrolyte imbalances and symptoms returning. Never attempt to “double up” on doses. Your vet may recommend blood work to check electrolyte levels before administering the next injection.
Can my dog live a normal life with Addison’s disease on Zycortal?
Yes! With proper treatment and monitoring, most dogs with Addison’s disease live full, normal, active lives. Zycortal effectively manages the hormone deficiency, allowing dogs to maintain normal activity levels, exercise, and quality of life. However, lifelong treatment and regular veterinary monitoring are essential for continued health.
Does Zycortal need to be refrigerated?
Yes, Zycortal must be stored in the refrigerator at 2-8°C (36-46°F). Do not freeze. Your veterinary clinic will maintain proper storage conditions. If you’re picking up medication for transport to your vet, keep it cool during transit and deliver it promptly for refrigerated storage.
Will my dog need other medications besides Zycortal?
Most dogs with Addison’s disease require glucocorticoid supplementation (typically prednisone or prednisolone) in addition to Zycortal. While Zycortal replaces the mineralocorticoid hormone (aldosterone), many dogs also need cortisol replacement. Your veterinarian will determine if additional medications are necessary based on your dog’s specific hormone deficiencies and response to treatment.
How do I know if Zycortal is working for my dog?
Effective treatment is indicated by resolution of Addison’s symptoms (improved energy, normal appetite, no vomiting/diarrhea) and normalized electrolyte levels on blood tests. Your veterinarian will monitor sodium and potassium levels through periodic blood work. Most dogs show significant improvement within the first few weeks of treatment and maintain stable health with continued therapy.
Can I order Zycortal Suspension online without seeing my vet?
Yes. Zycortal requires a valid veterinary prescription, which means your dog must be examined and diagnosed by a licensed veterinarian. Additionally, Zycortal injections must be administered by veterinary professionals this is not a medication you give at home. Your vet will prescribe Zycortal, and you can use that prescription to order from our licensed pet pharmacy for cost savings, but the medication will need to be delivered to your veterinary clinic for administration.
Is Zycortal covered by pet insurance?
Many pet insurance plans cover prescription medications for diagnosed conditions, including Addison’s disease treatment. Coverage varies by policy, so check with your specific insurance provider. You’ll typically need documentation of diagnosis and prescription from your veterinarian to submit claims. Some policies may require purchasing medications from specific pharmacies or may reimburse you for medication costs.
How to Order Zycortal from Our Pharmacy
Prescription Submission Process
Step 1: Obtain Prescription Your veterinarian must diagnose your dog with Addison’s disease and write a prescription for Zycortal Suspension.
Step 2: Submit Prescription You can submit your prescription by:
- Having your veterinarian fax it directly to us
- Uploading a photo/scan during checkout
- Mailing the original prescription
- Authorizing us to contact your vet for verification
Step 3: Prescription Verification Our licensed pharmacists will verify your prescription with your veterinarian before dispensing medication.
Step 4: Delivery We’ll ship your Zycortal in temperature-controlled packaging to ensure product integrity. Medication must be delivered to your veterinary clinic’s address for proper storage and administration.
Why Choose Our Pharmacy?
✓ Licensed & Accredited: NABP-accredited pharmacy with licensed veterinary pharmacists ✓ Competitive Pricing: Cost savings compared to purchasing directly from veterinary clinics ✓ Authentic Products: We source directly from manufacturers (Dechra) ✓ Temperature-Controlled Shipping: Proper cold chain maintenance for refrigerated medications ✓ Prescription Management: We’ll contact your vet for refill authorization when needed ✓ Customer Support: Knowledgeable staff available to answer questions
Important Safety Information
Before using Zycortal, inform your veterinarian if your dog:
- Has heart, kidney, or liver disease
- Is pregnant, nursing, or intended for breeding
- Is taking any other medications or supplements
- Has had allergic reactions to medications previously
This is a brief summary. For complete prescribing information, consult your veterinarian or request the full product insert.
Zycortal is a prescription medication that should only be used under veterinary supervision. Never give your dog medication prescribed for another animal.
