Description
Jurocyl 100ml Injection – Professional Oxytetracycline Antibiotic for Equine Bacterial Infections
Jurocyl 100ml Injection is a premium, veterinarian-prescribed oxytetracycline antibiotic solution manufactured by Ceva Animal Health for the professional treatment of bacterial infections in horses. This broad-spectrum tetracycline antibiotic provides rapid, effective control of susceptible bacterial pathogens while incorporating lidocaine hydrochloride to minimize injection discomfort.
Trusted by equine veterinarians and specialists across Australia, Jurocyl delivers consistent therapeutic results against a wide range of gram-positive and gram-negative bacteria, mycoplasma, and certain other pathogens affecting equine health. Its proven formulation ensures optimal bioavailability and sustained antibacterial activity for superior clinical outcomes.
Active Ingredients & Pharmaceutical Composition
Primary Active Ingredient:
Oxytetracycline Hydrochloride: 200mg/ml
- Broad-spectrum tetracycline-class antibiotic
- Bacteriostatic action against susceptible organisms
- Excellent tissue penetration and distribution
- Long half-life allowing extended dosing intervals
Secondary Active Ingredient:
Lidocaine Hydrochloride: 20mg/ml
- Local anesthetic to reduce injection pain
- Improves animal comfort during administration
- Minimizes injection site reactions
- Enhances treatment compliance
Pharmaceutical Excipients:
- Sterile water for injection
- Sodium formaldehyde sulfoxylate (antioxidant)
- Disodium edetate (chelating agent)
- Sodium hydroxide (pH adjustment)
- Hydrochloric acid (pH adjustment)
Mechanism of Action & Spectrum of Activity
How Oxytetracycline Works:
Jurocyl’s oxytetracycline component inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, preventing amino acid incorporation into growing peptide chains. This bacteriostatic action effectively controls bacterial multiplication while allowing the host immune system to eliminate existing pathogens.
Bacterial Spectrum Coverage:
Gram-Positive Bacteria:
- Streptococcus spp. (including S. equi)
- Staphylococcus spp.
- Corynebacterium spp.
- Clostridium spp. (selected strains)
- Actinobacillus spp.
Gram-Negative Bacteria:
- Pasteurella spp.
- Haemophilus spp.
- E. coli (susceptible strains)
- Klebsiella spp.
- Bordetella bronchiseptica
Other Pathogens:
- Mycoplasma spp.
- Chlamydia spp.
- Rickettsia spp. (selected species)
Clinical Indications & Therapeutic Applications
Respiratory Tract Infections:
- Bacterial pneumonia caused by susceptible organisms
- Upper respiratory tract infections (sinusitis, pharyngitis)
- Pleuropneumonia in conjunction with supportive care
- Secondary bacterial complications of viral respiratory disease
- Chronic obstructive pulmonary disease (COPD) bacterial components
Skin & Soft Tissue Infections:
- Bacterial dermatitis and skin fold infections
- Infected wounds and surgical site infections
- Cellulitis and subcutaneous infections
- Abscess formation (as adjunct to drainage)
- Post-surgical infection prevention (when indicated)
Systemic Bacterial Infections:
- Septicemia caused by susceptible organisms
- Bacteremia secondary to localized infections
- Joint infections (septic arthritis)
- Bone infections (osteomyelitis)
- Peritonitis and abdominal infections
Urogenital Tract Infections:
- Urinary tract infections (cystitis, urethritis)
- Reproductive tract infections in mares
- Endometritis caused by susceptible bacteria
- Mastitis in lactating mares (with veterinary supervision)
Professional Dosage & Administration Guidelines
Standard Dosing Protocol:
Primary Treatment Dose:
- Dosage: 1ml per 25kg body weight (8mg/kg oxytetracycline)
- Route: Deep intramuscular injection
- Frequency: Every 24-48 hours as determined by veterinarian
- Duration: 3-5 consecutive days or as clinically indicated
Dose Calculations by Horse Weight:
| Horse Weight | Jurocyl Dose | Injection Volume |
|---|---|---|
| 200kg (Pony) | 8ml | Single site |
| 300kg (Small Horse) | 12ml | Divide between 2 sites |
| 450kg (Average Horse) | 18ml | Divide between 2 sites |
| 600kg (Large Horse) | 24ml | Divide between 3 sites |
| 750kg (Draft Horse) | 30ml | Divide between 3 sites |
Injection Site Management:
Preferred Sites:
- Neck muscle (brachiocephalic or serratus ventralis)
- Gluteal muscles (deep injection)
- Semitendinosus/semimembranosus muscles
Administration Technique:
- Use 16-18 gauge needle, 1.5-2 inches long
- Rotate injection sites with multiple doses
- Maximum 10ml per injection site
- Maintain strict aseptic technique
- Massage injection site gently post-administration
Special Dosing Considerations:
Severe Infections: May require increased frequency (every 12-24 hours) for first 48-72 hours Chronic Conditions: Extended treatment courses with veterinary monitoring Renal Impairment: Reduce dose and extend intervals Hepatic Dysfunction: Monitor closely and adjust as needed
Treatment Duration & Monitoring
Standard Treatment Courses:
- Acute Infections: 3-5 days continuous treatment
- Respiratory Infections: 5-7 days or until 2 days post-clinical resolution
- Chronic/Severe Infections: 7-14 days with veterinary assessment
- Preventive Use: Single dose in high-risk situations (veterinary discretion)
Clinical Monitoring Requirements:
During Treatment:
- Daily clinical assessment by veterinarian
- Temperature monitoring (twice daily)
- Appetite and behavior evaluation
- Injection site examination for reactions
Laboratory Monitoring (Extended Use):
- Complete blood count (CBC) weekly
- Serum chemistry panel (liver/kidney function)
- Bacterial culture and sensitivity if no improvement
- Urinalysis for nephrotoxicity signs
Withdrawal Periods & Competition Regulations
Food Animal Withdrawal (If Applicable):
Meat: 28 days from last treatment Milk: Not for use in lactating animals producing milk for human consumption
Competition Horse Withdrawal Periods:
Racing/FEI Competition: Consult current regulations – typically 14-21 days Local Competition: Varies by organizing body Therapeutic Use Exemptions: May be available with veterinary documentation
⚠️ Important: Always verify current withdrawal requirements with relevant competition authorities and your veterinarian.
Contraindications & Precautions
Absolute Contraindications:
- Hypersensitivity to oxytetracycline or tetracycline antibiotics
- Severe renal insufficiency (creatinine >3.0 mg/dL)
- Severe hepatic dysfunction with encephalopathy
- Pregnancy (especially first trimester – teratogenic risk)
- Young animals with developing teeth/bones (under veterinary assessment only)
Relative Contraindications/Cautions:
- Concurrent nephrotoxic medications (aminoglycosides, NSAIDs)
- Electrolyte imbalances (severe dehydration)
- Previous adverse reactions to injectable antibiotics
- Concurrent calcium/iron supplementation (reduces absorption)
Drug Interactions:
Avoid Concurrent Use With:
- Bactericidal antibiotics (penicillins, cephalosporins) – antagonistic effects
- Oral anticoagulants – enhanced anticoagulation
- Methoxyflurane anesthesia – increased nephrotoxicity risk
- Calcium-containing IV solutions – precipitation risk
Adverse Effects & Management
Common Side Effects (1-5% incidence):
Injection Site Reactions:
- Mild swelling or inflammation
- Temporary soreness lasting 24-48 hours
- Occasional sterile abscess formation
Gastrointestinal Effects:
- Transient appetite reduction
- Mild diarrhea or soft stools
- Rare colitis in sensitive animals
Uncommon Side Effects (0.1-1% incidence):
Systemic Reactions:
- Transient fever (drug reaction)
- Mild depression or lethargy
- Rare photosensitivity reactions
Renal Effects (Extended Use):
- Temporary elevation in creatinine
- Proteinuria (usually reversible)
- Rare acute tubular necrosis
Emergency Management:
Severe Allergic Reactions:
- Discontinue treatment immediately
- Administer epinephrine if anaphylaxis
- Supportive care (IV fluids, corticosteroids)
- Contact veterinary emergency services
Storage & Stability Requirements
Storage Conditions of Jurocyl 100ml Injection:
- Temperature: Store below 25°C (77°F)
- Light Protection: Keep in original carton to prevent photodegradation
- Humidity: Protect from excessive moisture
- Freezing: Do not freeze – destroys activity
Stability Information:
- Shelf Life: 36 months from manufacture date (unopened)
- After Opening: Use within 28 days
- Color Changes: Discard if solution becomes dark or precipitates form
- Sterility: Maintain aseptic technique during use
Disposal Requirements:
- Follow local pharmaceutical waste disposal regulations
- Do not dispose in regular trash or water systems
- Return unused product to veterinary supplier if possible
- Maintain disposal records as required
Quality Assurance & Manufacturing Standards
Ceva Animal Health Manufacturing:
- GMP Certified: Good Manufacturing Practice compliance
- ISO Standards: International quality management systems
- Regulatory Approval: APVMA registered (Australia)
- Batch Documentation: Full traceability and testing records
Quality Control Testing:
Every Batch Tested For:
- Potency (oxytetracycline content)
- Sterility (bacterial/fungal contamination)
- Endotoxin levels (pyrogenicity)
- pH and osmolality
- Particulate matter
- Heavy metal contamination
Educational Resources:
- Administration Training: Proper injection techniques
- Treatment Protocols: Evidence-based therapy guidelines
- Case Studies: Real-world clinical applications
- Research Updates: Latest efficacy and safety data
Frequently Asked Questions
Q1: Where can I buy Jurocyl online in Australia legally?
Jurocyl 100ml Injection can be purchased from veterinary pharmaceutical distributors like Equinemedsplus.com with a valid veterinary prescription. Our online store is fully licensed for prescription veterinary medicine sales in Australia. A veterinary prescription and verification process are required before dispatch.
Q2: What bacterial infections does Jurocyl treat in horses?
Jurocyl (oxytetracycline) is effective against respiratory tract infections, skin and wound infections, urogenital tract infections, and systemic bacterial infections caused by susceptible gram-positive and gram-negative bacteria, mycoplasma, and other sensitive pathogens.
Q3: How is Jurocyl administered and what’s the proper dosage?
Jurocyl 100ml injection is administered by deep intramuscular injection at 1ml per 25kg body weight (8mg/kg). For horses over 300kg, divide the dose between multiple injection sites. Always follow your veterinarian’s specific dosing instructions and injection site recommendations.
Q4: What are the withdrawal periods for Jurocyl in competition horses?
Withdrawal periods vary by competition organization but typically range from 14-21 days. Always consult current regulations from your relevant governing body (Racing Australia, FEI, etc.) and your veterinarian before competition. Some therapeutic use exemptions may be available.
Q5: Can Jurocyl be used with other medications?
Jurocyl should not be used concurrently with bactericidal antibiotics (penicillins, cephalosporins) as they can be antagonistic. Avoid use with nephrotoxic drugs like aminoglycosides. Always inform your veterinarian of all medications and supplements your horse is receiving.
Q6: What are the storage requirements for Jurocyl?
Store Jurocyl below 25°C in the original packaging protected from light. Do not freeze. Once opened, use within 28 days while maintaining sterile technique. Discard if the solution becomes discolored or develops precipitates.
Q7: Are there any side effects with Jurocyl injection?
Common side effects include mild injection site swelling or soreness lasting 24-48 hours. Rare systemic reactions may include temporary appetite loss or mild gastrointestinal upset. Contact your veterinarian immediately if severe reactions occur.
Q8: Is Jurocyl safe for pregnant mares?
Jurocyl is contraindicated in pregnant mares, especially during the first trimester, due to potential teratogenic effects of tetracycline antibiotics. Consult your reproductive veterinarian for safe alternatives if bacterial treatment is needed during pregnancy.
Q9: How quickly does Jurocyl start working?
Jurocyl begins achieving therapeutic blood levels within 2-4 hours of injection. Clinical improvement is typically seen within 24-48 hours for acute infections. Complete resolution depends on infection severity and may take 3-7 days of treatment.
Q10: Can Jurocyl be used for wound treatment?
Yes, Jurocyl 100ml injection is excellent for treating infected wounds caused by susceptible bacteria. It’s particularly effective for deep tissue infections where topical antibiotics cannot penetrate adequately. Always combine with proper wound management and veterinary supervision.
Ordering Information & Professional Accounts
Product Specifications:
- Product Code: JUROCYL-100ML
- Package Size: 100ml sterile vial
- Minimum Order: 1 vial (prescription required)
- Bulk Pricing: Available for veterinary clinics (10+ vials)
- Professional Accounts: Special pricing for registered veterinarians
Shipping & Handling:
- Temperature-Controlled: Insulated packaging maintains stability
- Express Delivery: 24-48 hours Australia-wide
- Professional Packaging: Pharmaceutical-grade containers
- Tracking Included: Real-time shipment monitoring
- Insurance Coverage: Full product value protection
IMPORTANT SAFETY INFORMATION This product contains oxytetracycline and lidocaine. Not for use in animals producing milk or meat for human consumption during treatment and withdrawal periods. Report adverse events to Ceva Animal Health and APVMA. Store according to directions and dispose of responsibly.
